2011
1. Lu JP, Yuan XH, Ye QZ* (2011) Structural analysis of inhibition of Mycobacterium tuberculosis methionine aminopeptidase by bengamide derivatives, Eur J Med Chem, in press. pdb 3PKC | pdb 3PKD | pdb 3PKE
2. Wang WL, Chai SC, Ye QZ* (2011) Synthesis and biological evaluation of salicylate-based compounds as a novel class of methionine aminopeptidase inhibitors, Bioorg Med Chem Lett, 21, 7151-4. Abstract | Full text
3. Chai SC, Wang WL, Ding DR, Ye QZ* (2011) Growth inhibition of Escherichia coli and methicillin-resistant Staphylococcus aureus by targeting cellular methionine aminopeptidase, Eur J Med Chem, 46, 3537-40. Abstract | Full text
4. Lu JP, Yuan XH, Yuan H, Wang WL, Wan B, Franzblau SG, Ye QZ* (2011) Inhibition of Mycobacterium tuberculosis methionine aminopeptidases by bengamide derivatives, ChemMedChem, 6, 1041-8. Abstract | Full text | pdb 3PKA | pdb 3PKB
5. Yuan H, Chai SC, Lam CK, Xu HH, Ye QZ* (2011) Two methionine aminopeptidases from Acinetobacter baumannii are functional enzymes, Bioorg Med Chem Lett, 21, 3395-8. Abstract | Full text
   2010

6. Lu JP, Ye QZ* (2010) Expression and characterization of Mycobacterium tuberculosis methionine aminopeptidase type 1a, Bioorg Med Chem Lett, 20, 2776-9. Abstract | Full text
7. Chai SC, Ye QZ* (2010) A cell-based assay that targets methionine aminopeptidase in a physiologically relevant environment, Bioorg Med Chem Lett, 20, 2129-32. Abstract | Full text
8. Lu JP, Chai SC, Ye QZ* (2010) Catalysis and inhibition of Mycobacterium tuberculosis methionine aminopeptidase, J Med Chem, 53, 1329-37. Abstract | Full text | pdb 3IU7 | pdb 3IU8 | pdb 3IU9
   2009

9. Chai SC, Ye QZ* (2009) Analysis of the stoichiometric metal activation of methionine aminopeptidase, BMC Biochemistry, 10, 32. Abstract | Full text
10. Chai SC, Lu JP, Ye QZ* (2009) Determination of binding affinity of metal cofactor to the active site of methionine aminopeptidase based on quantitation of functional enzyme, Anal Biochem, 395, 263-4. Abstract | Full text
11. Chai SC, Ye QZ* (2009) Metal-mediated inhibition is a viable approach for inhibiting cellular methionine aminopeptidase, Bioorg Med Chem Lett, 19, 6862-4. Abstract | Full text
12. Zhao Y,Bacher A, Illarionov B, Fischer M, Georg G, Ye QZ, Fanwick PE, Franzblau SG, Wan B, Cushman M* (2009) Discovery and development of the covalent hydrates of trifluoromethylated pyrazoles as riboflavin synthase inhibitors with antibiotic activity against Mycobacterium tuberculosis, J Org Chem, 74, 5297-303. Abstract
13. Talukdar A, Breen M, Bacher A, Illarionov B, Fischer M, Georg G, Ye QZ, Cushman M* (2009) Discovery and development of a small molecule library with lumazine synthase inhibitory activity, J Org Chem, 74, 5123-34. Abstract | Full text
14. Wang WL, Chai SC, Ye QZ* (2009) Synthesis and structure-function analysis of Fe(II)-form-selective antibacterial inhibitors of Escherichia coli methionine aminopeptidase, Bioorg Med Chem Lett, 19, 1080-3. Abstract | Full text
    2008

15. Chai SC, Wang WL, Ye QZ* (2008) Fe(II) is the native cofactor for Escherichia coli methionine aminopeptidase, J Biol Chem, 283, 26879-85. Abstract | Full text
16. Wang WL, Chai SC, Huang M, He HZ, Hurley TD, Ye QZ* (2008) Discovery of inhibitors of Escherichia coli methionine aminopeptidase with the Fe(II)-form selectivity and antibacterial activity, J Med Chem, 51, 6110-20. Abstract | Full text | pdb 3D27
    
17. Vedantham P, Guerra JM, Schoenen F, Huang M, Gor PJ, Georg GI, Wang JL, Neuenswander B, Lushington GH, Mitscher LA, Ye QZ, Hanson PR* (2008) Ionic immobilization, diversification, and release: application to the generation of a library of methionine aminopeptidase inhibitors, J Comb Chem, 10, 185-94. Abstract
18. Vedantham P, Zhang M, Gor PJ, Huang M, Georg GI, Lushington GH, Mitscher LA, Ye QZ, Hanson PR* (2008) Studies towards the synthesis of methionine aminopeptidase inhibitors: diversification utilizing a ROMP-derived coupling reagent, J Comb Chem, 10, 195-203. Abstract
    2007

19. Ma ZQ, Xie SX, Huang QQ, Nan FJ, Hurley TD, Ye QZ* (2007) Structural analysis of inhibition of E. coli methionine aminopeptidase: implication of loop adaptability in selective inhibition of bacterial enzymes, BMC Struct Biol, 7, 84. Abstract | Full text | pdb 2Q92 | pdb 2Q93 | pdb 2Q94 | pdb 2Q95 | pdb 2Q96
20. Huang M, Xie SX, Ma ZQ, Huang QQ, Nan FJ, Ye QZ* (2007) Inhibition of monometalated methionine aminopeptidase: inhibitor discovery and crystallographic analysis, J Med Chem, 50, 5735-5742. Abstract | Full text | pdb 2P9A | pdb 2P99 | pdb 2P98
    
21. Zhang Y, Illarionov B, Bacher A, Fischer M, Georg GI, Ye QZ, Velde DV, Fanwick PE, Song Y, Cushman M* (2007) A novel lumazine synthase inhibitor derived from oxidation of 1,3,6,8-tetrahydroxy-2,7-naphthyridine to a tetraazaperylenehexaone derivative, J Org Chem, 72, 2769-76. Abstract | Full text
22. Galam L, Hadden MK, Ma Z, Ye QZ, Yun BG, Blagg BS, Matts RL* (2007) High-throughput assay for the identification of Hsp90 inhibitors based on Hsp90-dependent refolding of firefly luciferase, Bioorg Med Chem, 15, 1939-46. Abstract | Full text
23. Xie SX, Schalkhausser F, Ye QZ, Seifert R, Buschauer A* (2007) Effects of impromidine- and arpromidine-derived guanidines on recombinant human and guinea pig histamine H(1) and H(2 ) receptors. Arch Pharm (Weinheim), 340, 9-16. Abstract
24. Ahn YM, Vogeti L, Liu CJ, Santhapuram HKR, White JM, Vasandani V, Mitscher LA, Lushington GH, Hanson PR, Powell DR, Himes RH, Roby KF, Ye QZ, Georg GI* (2007) Design, synthesis, and antiproliferative and CDK2-cyclin A inhibitory activity of novel flavopiridol analogues, Bioorg Med Chem, 15, 702-13. Abstract
    2006

25. Ye QZ,* Xie SX, Ma ZQ, Huang M, Hanzlik RP (2006) Structural basis of catalysis by monometalated methionine aminopeptidase, Proc Natl Acad Sci USA, 103, 9470-5. Abstract | Full text | pdb 2GTX | pdb 2GU4 | pdb 2GU5 | pdb 2GU6 | pdb 2GU7
    
26. Xie SX, Petrache G, Schneider E, Ye QZ, Bernhardt G, Seifert R, Buschauer A* (2006) Synthesis and pharmacological characterization of novel fluorescent histamine H(2)-receptor ligands derived from aminopotentidine, Bioorg Med Chem Lett, 16, 3886-90. Abstract
27. Xie SX, Kraus A, Ghorai P, Ye QZ, Elz S, Buschauer A, Seifert R* (2006) N1-(3-Cyclohexylbutanoyl)-N2-[3-(1H-imidazol-4-yl)propyl]guanidine, a potent partial agonist for the human histamine H1- and H2-receptor, J Pharmacol Exp Ther, 317, 1262-8. Abstract
28. Avila C, Hadden MK, Ma Z, Kornilayev BA, Ye QZ, Blagg BS* (2006) High-throughput screening for Hsp90 ATPase inhibitors, Bioorg Med Chem Lett, 16, 3005-8. Abstract
29. Xie SX, Ghorai P, Ye QZ, Buschauer A, Seifert R* (2006) Probing ligand-specific histamine H1- and H2-receptor conformations with Ng-acylated imidazolylpropylguanidines, J Pharmacol Exp Ther, 317, 139-46. Abstract
30. Fang JW,* Dong YH, Lushington GH, Ye QZ, Georg GI (2006) Support vector machines in HTS data mining: Type I MetAPs inhibition study, J Biomol Screen, 11, 138-44. Abstract
31. Xie SX, Huang WJ, Ma ZQ, Huang M, Hanzlik RP, Ye QZ* (2006) Structural analysis of metalloform-selective inhibition of methionine aminopeptidase. Acta Crystallogr D Biol Crystallogr, 62, 425-32. Abstract | pdb 2EVM | pdb 2EVC | pdb 2EVO
    
32. Ma DW,* Jiang YW, Chen FP, Gong LK, Ding K, Xu Y, Wang RX, Ge AH, Ren J,* Li JY, Li J, Ye QZ (2006) Selective inhibition of matrix metalloproteinase isozymes and in vivo protection against emphysema by substituted gamma-Keto carboxylic acids, J Med Chem, 49,456-8. Abstract
33. Huang M, Xie SX, Ma ZQ, Hanzlik RP, Ye QZ* (2006) Metal mediated inhibition of methionine aminopeptidase by quinolinyl sulfonamides, Biochem Biophys Res Commun, 339, 506-13. Abstract | pdb 2BB7
    2005

34. Huang QQ, Huang M, Nan FJ,* Ye QZ* (2005) Metalloform-selective inhibition: Synthesis and structure-activity analysis of Mn(II)-form-selective inhibitors of Escherichia coli methionine aminopeptidase, Bioorg Med Chem Lett, 15, 5386-91. Abstract
35. Luo QL, Li JY, Liu ZY, Chen LL, Li J, Ye QZ, Nan FJ* (2005) Inhibitors of type I MetAPs containing pyridine-2-carboxylic acid thiazol-2-ylamide. Part 1: SAR studies on the determination of the key scaffold, Bioorg Med Chem Lett, 15, 635-8. Abstract
36. Luo QL, Li JY, Chen LL, Li J, Ye QZ, Nan FJ* (2005) Inhibitors of type I MetAPs containing pyridine-2-carboxylic acid thiazol-2-ylamide. Part 2: SAR studies on the pyridine ring 3-substituent, Bioorg Med Chem Lett, 15, 639-44. Abstract
37. Cui YM, Huang QQ, Xu J, Chen LL, Li JY, Ye QZ, Li J, Nan FJ* (2005) Identification of potent type I MetAP inhibitors by simple bioisosteric replacement. Part 1: Synthesis and preliminary SAR studies of thiazole-4-carboxylic acid thiazol-2-ylamide derivatives, Bioorg Med Chem Lett, 15, 3732-6. Abstract
38. Cui YM, Huang QQ, Xu J, Chen LL, Li JY, Ye QZ, Li J, Nan FJ* (2005) Identification of potent type I MetAPs inhibitors by simple bioisosteric replacement. Part 2: SAR studies of 5-heteroalkyl substituted TCAT derivatives, Bioorg Med Chem Lett, 15, 4130-5. Abstract
39. Haslam G, Richter M,* Wyatt D, Ye QZ, Kitos P (2005) Estimating the number of viable animal cells in multiwell culture-a tetrazolium-based assay, Anal Biochem, 336, 187-95. Abstract
40. Chen JH, Illarionov B, Bacher A, Fischer M, Haase I, Georg G, Ye QZ, Ma ZQ, Cushman M* (2005) A high-throughput screen utilizing the fluorescence of riboflavin for identification of lumazine synthase inhibitors, Anal Biochem, 338, 124-30. Abstract
    2004

41. Ye QZ,* Xie SX, Huang M, Huang WJ, Lu JP, Ma ZQ (2004) Metalloform-selective inhibitors of E. coli methionine aminopeptidase and X-ray structure of a Mn(II)-form enzyme complexed with an inhibitor, J Am Chem Soc, 126, 13940-1. Abstract | pdb 1XNZ,
    
42. Li JY, Cui YM, Chen LL, Gu M, Li J, Nan FJ,* Ye QZ* (2004) Mutations at the S1 sites of methionine aminopeptidases from Escherichia coli and Homo sapiens reveal the residues critical for substrate specificity, J Biol Chem, 279, 21128-34. Abstract
43. Li JY, Chen LL, Cui YM, Luo QL, Gu M, Nan FJ,* Ye QZ* (2004) Characterization of full length and truncated type I human methionine aminopeptidases expressed from Escherichia coli, Biochemistry, 43, 7892-8. Abstract
44. Cui YM, Li JY, Chen LL, Li J, Ye QZ, Nan FJ* (2004) Design and synthesis of chromogenic thiopeptolide substrates as MetAPs active site probes, Bioorg Med Chem, 12, 2853-61. Abstract
45. Chen LL, Li J, Li JY, Luo QL, Mao WF, Shen Q, Nan FJ, Ye QZ* (2004) Type I methionine aminopeptidase from Saccharomyces cerevisiae is a potential target for antifungal drug screening, Acta Pharmacol Sin, 25, 907-14. Abstract
46. Ma DW,* Wu WG, Yang G, Li J, Li JY, Ye QZ (2004) Tetrahydroisoquinoline based sulfonamide hydroxamates as potent matrix metalloproteinase inhibitors, Bioorg Med Chem Lett, 14, 47-50. Abstract
    2003

47. Li JY, Chen LL, Cui YM, Luo QL, Li J, Nan FJ,* Ye QZ* (2003) Specificity for inhibitors of metal-substituted methionine aminopeptidase, Biochem Biophys Res Commun, 307, 172-9. Abstract
48. Luo QL, Li JY, Liu ZY, Chen LL, Li J, Qian Z, Shen Q, Li Y, Lushington GH, Ye QZ,* Nan FJ* (2003) Discovery and structural modification of inhibitors of methionine aminopeptidases from Escherichia coli and Saccharomyces cerevisiae, J Med Chem, 46, 2631-40. Abstract
49. Cheng DH, Shen Q, Nan FJ, Qian Z, Ye QZ* (2003) Purification and characterization of catalytic domains of gelatinase A with or without fibronectin insert for high-throughput inhibitor screening, Protein Expr Purif, 27, 63-74. Abstract
    2002

50. Zhuang SF, Ye QZ* (2002) Cloning, expression and characterization of human vascular endothelial growth factor receptor 1 tyrosine kinase, Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai), 34, 39-44. In Chinese. Abstract
51. Zhuang SF, Zhou CH, Qian J, Qian Z, Shibuya M, Ye QZ* (2002) A new model for random screening inhibitors of vascular endothelial growth factor receptor 1 kinase, Acta Pharmacol Sin, 23, 117-23. Abstract
52. Cheng DH, Shen Q, Qian J, Qian Z, Ye QZ* (2002) Expression and purification of catalytic domain of human macrophage elastase for high throughput inhibitor screening, Acta Pharmacol Sin, 23, 143-51. Abstract
53. Shao ZY, Cai JN, Ye QZ, Guo YW (2002) Crassicaulisine, a new sulphonoglycolipid from the red alga Chondria crassicaulis Harv, J Asian Nat Prod Res, 4, 205-9. Abstract
    2001

54. Ma DW,* Wu WG, Qian J, Lang SH, Ye QZ (2001) Synthesis of a cyclic analogue of Galardin, Chinese J Chem, 19, 286-90.
55. Qian J, Zhou CH, Qian Z, Nan FJ, Ye QZ* (2001) Development of a K562 cell-based assay for screening anticancer agents, Acta Pharmacol Sin, 22, 821-6. Abstract
    2000

56. Ye QZ,* Nan FJ, Hu LY, Qian Z, Qian J (2000) High-throughput screening for human collagenase 1 inhibitors, Acta Pharmacol Sin, 21, 1021-6. Abstract
57. Hu LY, Tian SM, Ye QZ, Ruan KC* (2000) Comparison of the catalytic domains of collagenase-1 and stromelysin-1, Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai), 32, 409-412. In Chinese. Abstract
    1999

58. Du ZY, Li XY,* Ye QZ* (1999) The structural features and inhibitors of tumor necrosis factor-alpha converting enzyme, Sheng Li Ke Xue Jin Zhan, 30, 245-8. Review, in Chinese. Abstract
59. Wang Y, Johnson AR, Ye QZ, Dyer RD* (1999) Catalytic activities and substrate specificity of the human membrane type 4 matrix metalloproteinase catalytic domain, J Biol Chem, 274, 33043-9. Abstract
60. Pavlovsky AG, Williams MG, Ye QZ, Ortwine DF, Purchase CF, White AD, Dhanaraj V, Roth BD, Johnson LL, Hupe D, Humblet C, Blundell TL* (1999) X-ray structure of human stromelysin catalytic domain complexed with nonpeptide inhibitors: implications for inhibitor selectivity, Protein Sci, 8, 1455-62. Abstract | pdb 1CAQ | pdb 1CIZ | pdb 1B8Y | pdb 1QIA | pdb 1QIC
61. Dhanaraj V, Williams MG, Ye QZ, Molina F, Johnson LL, Ortwine DF, Pavlovsky A, Rubin JR, Skeean RW, White AD, Humblet C, Hupe DJ, Blundell TL* (1999) X-Ray structure of gelatinase A catalytic domain complexed with a hydroxamate inhibitor, Croatica Chem Acta, 72, 575.
    1998

62. Cha J, Sorensen MV, Ye QZ, Auld DS* (1998) Selective replacement of the catalytic zinc of the human stromelysin-1 catalytic domain, J Biol Inorg Chem, 3, 353-9.
    1996

63. Dhanaraj V, Ye QZ, Johnson LL, Hupe DJ, Ortwine DF, Dunbar JB Jr, Rubin JR, Pavlovsky A, Humblet C, Blundell TL* (1996) X-ray structure of a hydroxamate inhibitor complex of stromelysin catalytic domain and its comparison with members of the zinc metalloproteinase superfamily, Structure, 4, 375-86. Abstract
64. Wang KK,* Nath R, Posner A, Raser KJ, Buroker-Kilgore M, Hajimohammadreza I, Probert AW, Marcoux FW, Ye QZ, Takano E, Hatanaka M, Maki M, Caner H, Collins JL, Fergus A, Lee KS, Lunney EA, Hays SJ, Yuen P (1996) An alpha-mercaptoacrylic acid derivative is a selective nonpeptide cell-permeable calpain inhibitor and is neuroprotective, Proc Natl Acad Sci USA, 93, 6687-92. Abstract
65. Ye QZ,* Hupe D, Johnson L (1996) Catalytic domains of matrix metalloproteinases: A molecular biology approach to drug discovery, Current Med Chem, 3, 407-18. Review.
66. Ye QZ,* Hupe D (1996) Catalytic domains of matrix metalloproteinases: Molecular biology in drug research, Ziran Zazhi, 18, 331-8. Review, in Chinese.
67. Shipley JM, Doyle GA, Fliszar CJ, Ye QZ, Johnson LL, Shapiro SD, Welgus HG, Senior RM* (1996) The structural basis for the elastolytic activity of the 92-kDa and 72-kDa gelatinases. Role of the fibronectin type II-like repeats, J Biol Chem, 271, 4335-41. Abstract
68. Dhanaraj V, Ye QZ, Johnson LL, Hupe DJ, Ortwine DF, Dunbar JB, Rubin JR, Pavlovsky A, Humblet C, Blundell TL* (1996) Designing inhibitors of the metalloproteinase superfamily: Comparative analysis of representative structures, Drug Des Discov, 13, 3-14. Abstract
    1995

69. Ye QZ,* Johnson LL, Yu AE, Hupe D (1995) Reconstructed 19 kDa catalytic domain of gelatinase A is an active proteinase, Biochemistry, 34, 4702-8. Abstract.
70. Van Doren SR, Kurochkin AV, Hu W, Ye QZ, Johnson LL, Hupe DJ, Zuiderweg ER* (1995) Solution structure of the catalytic domain of human stromelysin complexed with a hydrophobic inhibitor, Protein Sci, 4, 2487-98. Abstract | pdb 1UMS | pdb 1UMT
    1994

71. Ye QZ,* Johnson LL, Nordan I, Hupe D, Hupe L (1994) A recombinant human stromelysin catalytic domain identifying tryptophan derivatives as human stromelysin inhibitors, J Med Chem, 37, 206-9. Abstract
72. Baragi VM, Fliszar CJ, Conroy MC, Ye QZ, Shipley JM, Welgus HG (1994) Contribution of the C-terminal domain of metalloproteinases to binding by tissue inhibitor of metalloproteinases. C-terminal truncated stromelysin and matrilysin exhibit equally compromised binding affinities as compared to full-length stromelysin, J Biol Chem, 269, 12692-7. Abstract
73. Hu P, Ye QZ, Loo JA* (1994) Calcium stoichiometry determination for calcium binding proteins by electrospray ionization mass spectrometry, Anal Chem, 66, 4190-4. Abstract
74. Soler D, Nomizu T, Brown WE, Chen M, Ye QZ, Van Wart HE, Auld DS* (1994) Zinc content of promatrilysin, matrilysin and the stromelysin catalytic domain, Biochem Biophys Res Commun, 201, 917-23. Abstract
    1993

75. Van Doren SR, Kurochkin AV, Ye QZ,* Johnson LL, Hupe DJ, Zuiderweg ER* (1993) Assignments for the main-chain nuclear magnetic resonances and delineation of the secondary structure of the catalytic domain of human stromelysin-1 as obtained from triple-resonance 3D NMR experiments, Biochemistry, 32, 13109-22. Abstract
76. Heath TG, Thanabal V,* Ye QZ (1993) Rapid, accurate and sensitive determination of molecular weight of 15N and 13C labeled recombinant proteins by electrospray ionization mass spectrometry, Biotechnol Tech, 7, 367-72.
77. Holler TP,* Foltin SK, Ye QZ, Hupe DJ (1993) HIV1 integrase expressed in Escherichia coli from a synthetic gene, Gene, 136, 323-8. Abstract
    1992

78. Ye QZ,* Johnson LL, Baragi V (1992) Gene synthesis and expression in E. coli for pump, a human matrix metalloproteinase, Biochem Biophys Res Commun, 186, 143-9. Abstract
79. Ye QZ,* Johnson LL, Hupe DJ, Baragi V (1992) Purification and characterization of the human stromelysin catalytic domain expressed in Escherichia coli, Biochemistry, 31, 11231-5. Abstract
80. Ahn Y, Ye QZ, Cho H, Walsh CT, Floss HG* (1992) Stereochemistry of carbon-phosphorus cleavage in ethylphosphonate catalyzed by C-P lyase from Escherichia coli, J Am Chem Soc, 114, 7953-4.
    1991

81. Anderson KS, Kati WM, Ye QZ, Liu J, Walsh CT, Benesi AJ, Johnson KA* (1991) Isolation and structure elucidation of the 4-amino-4-deoxychorismate intermediate in the PABA enzymatic pathway, J Amer Chem Soc, 113, 3198-200.
    1990

82. Chen CM, Ye QZ, Zhu ZM, Wanner BL, Walsh CT* (1990) Molecular biology of carbon-phosphorus bond cleavage. Cloning and sequencing of the phn (psiD) genes involved in alkylphosphonate uptake and C-P lyase activity in Escherichia coli B, J Biol Chem, 265, 4461-71. Abstract
83. McDermott AE, Creuzet F, Griffin RG, Zawadzke LE, Ye QZ, Walsh CT* (1990) Rotational resonance determination of the structure of an enzyme-inhibitor complex: phosphorylation of an (aminoalkyl)phosphinate inhibitor of D-alanyl-D-alanine ligase by ATP, Biochemistry, 29, 5767-75. Abstract
84. Ye QZ, Liu J, Walsh CT* (1990) p-Aminobenzoate synthesis in Escherichia coli: purification and characterization of PabB as aminodeoxychorismate synthase and enzyme X as aminodeoxychorismate lyase, Proc Natl Acad Sci USA, 87, 9391-5. Abstract
    1989

85. Grunewald GL,* Ye QZ, Sall DJ, Criscione KR, Wise B (1989) Conformational and steric aspects of phenylethanolamine and phenylethylamine analogues as substrates or inhibitors of phenylethanolamine N-methyltransferase, Mol Pharmacol, 35, 93-7. Abstract
86. Ye QZ, Grunewald GL* (1989) Conformationally restricted and conformationally defined tyramine analogues as inhibitors of phenylethanolamine N-methyltransferase, J Med Chem, 32, 478-86. Abstract
    1988

87. Grunewald GL,* Ye QZ, Kieffer L, Monn JA (1988) Conformational requirements of substrates for activity with phenylethanolamine N-methyltransferase, J Med Chem, 31, 169-71.Abstract
88. Grunewald GL,* Ye QZ. (1988) Stereochemical aspects of phenylethanolamine analogues as substrates of phenylethanolamine N-methyltransferase, J Med Chem, 31, 1984-6. Abstract
89. Grunewald GL,* Ye QZ (1988) Synthesis of benzobicyclo[3.2.1]octanes involving inversion of configuration via an N to O acetyl migration, J Org Chem, 53, 4021-6.
    1987

90. Grunewald GL,* Ye QZ, Takusagawa F (1987) Structures of two isomeric phenylethanolamine analogs containing the benzobicyclo[3.2.1]octane skeleton, Acta Crystallogr, C43, 2418-20.

* corresponding author

Patents

1. Yuan CS, Ye QZ, Xie SX. Methods for assaying inhibitors of S-adenosylhomocysteine (SAH) hydrolase and S-adenosylmethionine (SAM)-dependent methyltransferase. US Patent No. 7,384,760, Issued on June 10, 2008.
2. Ye QZ, Johnson LL, Hupe DJ, Baragi V. Process for the production of stromelysin catalytic domain protein. US patent No. 6,284,513. Issued on Sept. 4, 2001.
3. Hupe DJ, Johnson LL, Ortwine DF, Purchase CF, White AD, Ye QZ. Aromatic keto-acids and their derivatives as inhibitors of matrix metalloproteinases. US patent No. 6,008,220. Issued on Dec. 28, 1999.
4. Hupe DJ, Johnson LL, Armand JA, White AD, Ye QZ. Tricyclic inhibitors of matrix metalloproteinases. US patent No. 5,958,972. Issued on Sept. 28, 1999.
5. Hupe DJ, Johnson LL, Armand JA, White AD, Ye QZ. Tricyclic inhibitors of matrix metalloproteinases. US patent No. 5,665,764. Issued on Sept. 9, 1997.
6. Ye QZ, Johnson LL, Hupe DJ. Process for the production of gelatinase catalytic domain protein. US patent No. 5,646,027. Issued on July 8, 1997.
7. Hupe DJ, Johnson LL, Ye QZ. Tricyclic inhibitor of matrix metalloproteinases. US patent No. 5,627,206. Issued on May 6, 1997.

X-ray (and NMR) structures in PDB data bank from this laboratory

E. coli methionine aminopeptidase

• With a Co(II)-form selective inhibitor: 2EVO
• With Mn(II)-form selective inhibitors: 1XNZ, 2EVM, 2EVC, 2Q92, 2Q93, 2Q94, 2Q95, 2Q96
• With a Fe(II)-form selective inhibitor: 3D27
• With monometalated-form specific inhibitors: 2P9A, 2P99, 2P98
• With implication of a monomatelated catalytic site: 2GTX, 2GU4, 2GU5, 2GU6, 2GU7
• With a metal-dependent inhibitor: 2BB7

M. tuberculosis methionine aminopeptidase

• With a Mn(II)-form selective inhibitor: 3IU7
• With Ni(II)-form selective inhibitors: 3IU8, 3IU9
• With bengamide derivatives: 3PKA, 3PKB, 3PKC, 3PKD, 3PKE

Human stromelysin

• With nonpeptidic inhibitors: 1CAQ, 1CIZ, 1B8Y
• Without an inhibitor: 1QIA, 1QIC
• NMR solution structures with a nonpeptidic inhibitor: 1UMS, 1UMT