Molecular Basis of PTP Substrate Recognition and Catalysis

Mechanistic studies with physiological substrates (i.e. phosphoproteins), site-directed mutagenesis, expressed-protein ligation, X-ray crystallography, H/D exchange-mass spectrometry to probe protein dynamics and interaction.

Activity-based and Interaction Proteomics

Mechanism-based probes to profile PTPs in both normal physiology and pathological conditions. Isolation, identification, and characterization of PTP substrates/regulators.

Chemical Genetics

Combinatorial chemistry and high throughput screening approaches to acquire potent and selective PTP inhibitors as tools to modulate PTP functions.

Roles of PTP in Signaling and in Diseases

A number of projects are available to elucidate the roles of PTPs implicated in diabetes, cancer, and bacterial pathogenesis.


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